Therefore, BCL-XL-selective inhibitors have the potential to enhance the efficacy of docetaxel in solid tumors and avoid the exacerbation of neutropenia observed with navitoclax. By contrast, selectively inhibiting BCL-XL did not suppress granulopoiesis but was highly efficacious in combination with docetaxel when tested against a range of solid tumors. scott.campbell-taylor 2 months ago in reply to m. All devices at that site in the LAN Group have a dependency on the WAN Group parent nd therefore do not generate any alert output. The WAN Group for the site these 2 devices below is now in a Down status 1 Group down alert.
#TYPESTATUS 2 DEPENDENCIES OFFLINE#
Selective BCL-2 inhibition suppressed granulopoiesis in vitro and in vivo, potentially accounting for the exacerbated neutropenia observed when navitoclax was combined with docetaxel clinically. The 2 WAN tier routers both go offline 2 Node Down Alerts. We used venetoclax and the BCL-XL-selective inhibitors A-1155463 and A-1331852 to assess the relative contributions of inhibiting BCL-2 or BCL-XL to the efficacy and toxicity of the navitoclax-docetaxel combination. Navitoclax has also been shown to enhance the efficacy of docetaxel in preclinical models of solid tumors, but clinical use of this combination has been limited by neutropenia. This prompted the generation of the BCL-2-selective inhibitor venetoclax (ABT-199/GDC-0199), which demonstrates robust activity in these cancers but spares platelets. However, its efficacy in these settings is limited by thrombocytopenia caused by BCL-XL inhibition. If you create your endpoint using JAX-RS, this extension will create request metrics automatically.The BCL-2/BCL-XL/BCL-W inhibitor ABT-263 (navitoclax) has shown promising clinical activity in lymphoid malignancies such as chronic lymphocytic leukemia. Adding in ContainerRequestContextĪdd in the setProperty the same key used in error-message, or use error-info, then put your string content for the error.
Adding in the headerĪdd in the response header the same key used in error-message, or use error-info, then put your string content for the error.
#TYPESTATUS 2 DEPENDENCIES CODE#
The errors messages will be added only when the status code is greater than or equal 400. If it is not found it will look in the properties of ContainerRequestContext. This extension will look first in the header, Key for error messages in the header or request attributeįirst you need to define the key in error-message in the properties, default value is error-info.Ĭhoose your way, by the header or adding the property in ContainerRequestContext. Values in seconds for the buckets used in b5 metrics For example: Depends: mobilesubstrate, something-else, some-other-package, ws.hbang.typestatus2 (> 2.
List of paths comma-separated where metrics do not apply If TypeStatus isn’t present on the device, your binaries will fail to load. These are properties that you can use to config your b5 quarkus monitor, all properties will start with quarkus.b5.monitor Property Nameĭefine the path where the metrics are exposed. Import the following dependency to your project( check the latest version in the Maven badge at the beginning of this README): Maven You can create your own dependency_request metric using addDependencyEvent method in MonitorMetrics to add a new dependency request event. If you needed to create your own dependency_up metric, you can use the addDependenc圜hecker method in MonitorMetrics to add a checker if your dependency is up or down. If status code is greater than or equal 500 it will be consider down. If the request made using RestClient returns a status code between 200 and 499 it will be considered up, The addr tag will be filled with path in the same pattern used in JAX-RS, like Dependency_up Which are dependency_up and dependency_request. In this implementation, all requests made using rest client will create two metrics, The name of the dependency is the interface name which defines the RestClient. The dependency metrics are collectedīy a MicroProfile Rest Client Provider implementation. This project defines as Dependency any service called through REST. The addr tag will be filled with the path in the same pattern used in JAX-RS, like if you need to create your own request metric you could use the addRequestEvent method in MonitorMetrics.
So only the endpoint using JAX-RS will have its metrics created automatically, and you can disable it using the exclusion path configuration. The filters in the request metric type are created using ContainerRequestFilter, ContainerResponseFilter from JAX-RS, In this project we have three types of metrics, request, dependency and application info, the first two are created using filters, the third is for holding static version info. Name registers the name of the dependency IsError lets us know if the status code reported is an error or not ĮrrorMessage registers the error message, passed by headers or property in ContainerRequestContext or Version tells which version of your app handled the request